That portion of an immunoglobulin molecule (Fragment crystallizable) that binds to a cell when the antigen binding sites (Fab) of the antibody are occupied or the antibody is aggregated; the Fc portion is also important in complement activation. The Fc fragment can be separated from the Fab portions by pepsin. Fc moieties from different antibody classes and subclasses have different properties.

Dictionary of molecular biology. 2004.

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